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Home > Herbs A - Z > L-Arginine
Home > Herbs A - Z > Amino Acids > L-Arginine
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L-Arginine
L-Arginine is a semi-essential amino acid synthesized by the body from ornithine. Arginine supports protein synthesis as it is involved in the transport and storage of nitrogen. Arginine is important for proper physical performance because it is used by the body to produce creatine. Each tablet contains 1000 mg elemental L-Arginine from 1204 mg L-Arginine Hydrochloride.
L-arginine is a protein amino acid present in the proteins of all life forms. It is classified as a semi-essential or conditionally essential amino acid. This means that under normal circumstances the body can synthesize sufficient L-arginine to meet physiological demands. There are, however, conditions where the body cannot. L-arginine is essential for young children and for those with certain rare genetic disorders in which synthesis of the amino acid is impaired. Some stress conditions that put an increased demand on the body for the synthesis of L-arginine include trauma (including surgical trauma), sepsis and burns. Under these conditions, L-arginine becomes essential, and it is then very important to ensure adequate dietary intake of the amino acid to meet the increased physiological demands created by these situations.
L-arginine, even when it is not an essential amino acid as defined above, is a vital one. In addition to participating in protein synthesis, it plays a number of other roles in the body. These include the detoxification of ammonia formed during the nitrogen catabolism of amino acids via the formation of urea. In addition, L-arginine is a precursor in the formation of nitric oxide, creatine, polyamines, L-glutamate, L-proline, agmatin (a possible neurotransmitter in the brain) and the arginine-containing tetrapeptide tuftsin, believed to be an immunomodulator. L-arginine is a glycogenic amino acid; it can be converted to D-glucose and glycogen if needed by the body or it can be catabolized to produce biological energy.
L-arginine, when administered in high doses, stimulates pituitary release of growth hormone and prolactin and pancreatic release of glucagon and insulin. Intravenous L-arginine may be used as an aid in the evaluation of problems with growth and stature that may be due to growth hormone deficiency. Intravenous arginine hydrochloride may be used as a fourth-line agent in the treatment of severe metabolic alkalosis. L-arginine is also used as an immunonutrient in enteral and parenteral nutrition to help improve the immune status in those suffering from sepsis, burns and trauma.
L-arginine is predominately synthesized in the kidney. It is a key intermediate in the Krebs-Henseleit urea cycle. L-ornithine and L-citrulline are precursors in the synthesis of L-arginine, and L-arginine is converted to urea and L-ornithine via the enzyme arginase. The portion of L-arginine that is not converted to urea enters the circulation, and is distributed to the various tissues and metabolized as discussed above. A much smaller amount of L-arginine is produced in the liver.
The typical dietary intake of L-arginine is 3.5 to 5 grams daily. Most dietary L-arginine comes from plant and animal proteins. Small amounts of free L-arginine are found in vegetable juices and fermented foods, such as miso and yogurt. Soy protein and other plant proteins are richer in L-arginine than are animal proteins, which are richer in lysine. It is thought that the possible hypocholesterolemic effect of soy protein is due, at least in part, to the higher L-arginine content in this protein.
L-Arginine Facts
L-Arginine is a nonessential amino acid (the body can produce it on its own) and it is necessary for normal functioning of the pituitary gland. Males, whose seminal fluids contain up to 80% of this protein building block, especially need l-arginine for a deficiency could lead to infertility. As people age the production of L-Arginine decreases and many experts believe this is responsible for many degenerative processes related to aging, thus it plays an important role in maintaining health (including sexual health).
How it Works
L-Arginine, through its availability and metabolization of nitric oxide (a gas that's responsible for transmitting important signals and regulating cellular functions in the body), has many beneficial effects. It dilates and engorges the blood vessels in the penis and clitoris, facilitating erections in males and genital responsiveness in females. L-Arginine assists with maximum sexual performance by increasing the supply of nitric oxide in the body, resulting in strong erections and increased sexual functions. L-Arginine has other health-related benefits related to regulating the blood pressure including improving blood flow, reducing plaque build-up, and lowering cholesterol.
Possible Benefits of L-Arginine
L-Arginine Helps achieve maximum sexual performance and increase sexual function.
L-Arginine Assists males with stronger, larger erections.
L-Arginine Assists females by enlarging clitoris and making it more responsive.
L-Arginine Increases sensitivity to the sexual organs for orgasms.
L-Arginine Regulates blood pressure, reduces plaque, lowers cholesterol, and prevents blood clots.
L-Arginine Helps long term memory and olfactory sensations.
L-Arginine Controls and fights infections.
L-Arginine Acts as an antiaging nutrient.
L-Arginine Enhances sexual functions when taken with ginkgo biloba and yohimbe.
L-Arginine Increases blood flow throughout the body and to the sexual organs.
Some Natural Sources
Nuts, sunflower seeds, sesame seeds, chocolate, popcorn, raisins, brown rice, carob, gelatin desserts, oatmeal, whole wheat bread, and protein rich foods.
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