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Home > Herbs A - Z > L-Glutamine
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L-Glutamine
L-Glutamine: The Conditionally Essential Amino Acid
Glutamine is one of the 20 amino acids our body uses to build proteins. These proteins are the building blocks for most components of our bodies, including muscles, bones, hair, hormones and more. Glutamine plays a vital role in the proper functioning of many body systems, including the immune and digestive systems. Due to its importance in the body, the use of glutamine supplementation is the focus of intense research efforts.
Of the 20 amino acids in our bodies, nine are considered "essential" and the other 11 are termed "non-essential." The essential amino acids need to be obtained from our diet, as opposed to the non-essential ones, which our body can manufacture on its own. When we eat, the proteins we ingest are broken down by our digestive system into their individual amino acids. By linking amino acids back together in various combinations, our body synthesizes the proteins it needs.
Since we are capable of making glutamine on our own, it was originally labeled a non-essential amino acid. However, most scientists now consider glutamine to be a "conditionally" essential amino acid, because under certain conditions we are unable to make adequate amounts and thus need to obtain it from outside sources. Studies have shown that our body's concentration of glutamine is markedly decreased during times of severe bodily stress, such as during major surgery, burns, starvation, serious infections and even prolonged exercise.
Glutamine is the most abundant amino acid in our bodies, comprising approximately half of the free amino acids in our muscles and blood. The majority of our glutamine is manufactured and stored in skeletal muscle. While our bodies synthesize most of the glutamine that we need, we also obtain some from the foods we eat. Practically all proteins we consume contain some amount of glutamine, usually in the order of 4% to 8% of their total amino acid composition. Given the average adult's daily protein intake, we probably obtain less than 10 grams of glutamine from our diet each day.
L Glutamine Protects Muscle Tissue and Supports Immune Function!
Glutamine is the most abundant amino acid in the body and is involved in many metabolic processes. Skeletal muscles are the primary sites of glutamine concentration. There is an increased demand for glutamine during stress associated with exercise, illness or trauma. Glutamine supplementation supports protein synthesis as well as the rate of glycogen production by serving as a carbon donor. Glutamine also serves as a fuel source for intestinal muscosal cells and nucleotide synthesis by lymphyctes.
For years athletes and bodybuilders have been looking for a product to help them recover faster from workouts and competition, keep their muscles well hydrated for maximum growth and provide numerous other benefits in the muscle building process. In recent years most athletes have come to understand the benefits of L-Glutamine. Now further research into this topic reveals, the benefit may be greater than we had first thought.
L-Glutamine is the most abundant amino acid in the body, and makes up more than 60% of the intramuscular amino acid pool. L-Glutamine plays an important role in many body functions such as proper immune system function, the transfer of nitrogen between organs, precursor to DNA, and regulation of protein synthesis and degradation.
L-Glutamine is vital in treating alcoholism, sugar cravings, epilepsy, mental disorders, maintaining blood sugar levels, enhancing gut immune function, bodybuilding, endurance, fat metabolism, regulating carbohydrate and protein, preventing lactic acid build up, brain and nerve functions, GI tract integrity, joint, and soft tissue maintenance.
Following an intense workout your body needs to replenish glutamine stores to aid in recovery, L-Glutamine can help increase muscle cell hydration and aid in protein synthesis. These and more functions of L-Glutamine can benefit athletes and bodybuilders by improving recovery and performance.
Ideal uses of L-Glutamine include:
L-Glutamine Increase muscle cell volume
L-Glutamine Boost immune system function
L-Glutamine Increase muscle protein synthesis
Two thirds of the free form amino acids inside your muscle are comprised of L-glutamine. L-Glutamine may help to improve muscle recovery, and assist in recovery from catabolic conditions.
L Glutamine Research
Glutamine plays many roles in our body. Research has shown glutamine to be integral in the proper function of our digestive system, our immune system (our ability to fight infection) and our muscular system, to name a few. It acts as a type of fuel for cells, especially for rapidly dividing cells such as enterocytes, colonocytes, lymphocytes and fibroblasts. During the manufacture of glutamine, a nitrogen molecule is taken from free ammonia in the body, thus it plays a role in protecting our bodies from high levels of ammonia and maintaining proper acid-base balance. When needed, our body can convert glutamine to sugar for energy. Glutamine is also involved in the manufacture of other amino acids, including glutathione, an important intracellular antioxidant.
Can glutamine supplementation help us in our goal of living a longer, healthier life?
To explore this, we will examine glutamine's role in its two most active body systems: the digestive and immune systems. We will also discuss the relationship between exercise and glutamine. While a comprehensive review of the research was performed in the preparation of this article, it is important to bear in mind that the references used do not necessarily represent an exhaustive list of published research on glutamine and its use as a supplement.
The Digestive System
Numerous studies have shown glutamine to be a key component in the maintenance of healthy intestinal mucosa. In fact, glutamine was once termed "intestinal permeability factor." The small intestine is by far the greatest user of glutamine in the body. Enterocytes (epithelial cells lining the small intestine) use glutamine as their primary fuel for metabolic function. It is felt that a lack of glutamine leads to a loss of epithelial cell integrity in the lining of the intestines. This, in turn, may allow toxins and infectious agents to enter the body. Most research studies concerning glutamine and the gastrointestinal system involve the addition of glutamine to TPN (total parenteral nutrition), a nutritional supplement given to the critically ill. One study showed that the addition of glutamine to TPN solutions reversed intestinal mucosal atrophy. Although glutamine has been shown to be beneficial when added to TPN solution in critically ill patients, its role in other gastrointestinal disease is still controversial and more studies are needed to determine its potential benefits and drawbacks.
The Immune System
Glutamine plays a major role in our infection-fighting "immune" system. Many immune cells, such as lymphocytes and macrophages, use glutamine as an energy source almost as much, if not more than, the amount of glucose they use for energy. Some studies have shown a benefit of glutamine in chemotherapy and bone marrow transplant patients, whom usually have a weakened immune system. Yet other research has shown that glutamine can help reduce infections in critically ill patients. In addition, glutamine may play a role in enhancing the weakened immune systems of athletes after prolonged strenuous exercise, which is discussed in further detail in the next section.
Exercise
Glutamine regulation may be especially important in athletes, both to help ward off infections and to prevent the breakdown of muscle. Studies have shown that while glutamine levels rise after short-term exercise, they decrease after prolonged periods of exercise. It has been theorized that after exhaustive exercise, such as running a marathon, athletes are at an increased risk of acquiring an infection. This is possibly due to decreased glutamine levels. On the other hand, it should be noted that regular, moderate exercise has been shown to reduce the incidence of illness in sedentary individuals (yet another reason regular exercise can improve your health and longevity).
Research has shown that glutamine appears to be involved in the regulation of a number of important metabolic processes in skeletal muscle. It is therefore hypothesized that glutamine supplementation can help maintain muscle mass. Under severe stress conditions, when glutamine levels are low, the body may respond by breaking down muscle to obtain glutamine. Therefore, experts believe that if supplemental glutamine is taken during these situations, the unnecessary breakdown of muscle may be prevented. In fact, researchers believe that glutamine supplementation may increase protein synthesis in the body.
Overall, it seems that glutamine supplementation can benefit certain athletes, possibly by boosting the immune system and preventing the breakdown of muscle. This may be especially important during times of excessive stress, such as after prolonged strenuous exercise. However, a great deal of information about the role of glutamine during athletic activity is still unclear and will hopefully be clarified by future research.
Conclusion
Glutamine, the most abundant amino acid in humans, is vital to the proper functioning of our bodies. Research has clearly shown that glutamine is necessary for proper intestinal health and that it plays a major role in fighting infections by acting as a fuel for cells in our immune system. Glutamine supplementation is important for the critically ill and may play a role in helping athletes after prolonged strenuous exercise by decreasing infections and preventing the breakdown of muscle. While the role of glutamine in these and other situations is promising, additional research is needed. The role of glutamine in the body and the potential advantages of glutamine supplementation for both sick and healthy individuals is the focus of on-going intense research efforts throughout the world.
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